Zantac 360 (famotidine) is an over-the-counter (OTC) medication used to help with heartburn. It works as a histamine-2 (H2) antagonist to lower the amount of stomach acid. Zantac 360 with Triple Action: prevents, relieves, and lasts. Zantac 360 starts working in as little as 15 minutes and controls stomach acid production for up to 12 hours*. Good food, great company, zero interruptions. Zantac 360°® prevents heartburn, relieves it fast, and lasts for up to 12 hours*. *Refers to acid control. Acid control does not correlate to symptom relief. Use as directed. Fast-acting heartburn relief & acid reflux medicine; acid reducer in easy-to-swallow tablets for powerful 12-hour protection. Zantac (ranitidine) was used to treat or prevent heartburn or acid reflux. It was recalled in April 2020 and replaced with Zantac 360 (famotidine). Zantac is used to treat and prevent ulcers in the stomach and intestines. Includes Zantac side effects, interactions, indications, recalls, cancer risk warnings, FDA alerts, and news updates. In 2021, Zantac relaunched with a new name and different active ingredient — Zantac 360 (famotidine). Famotidine doesn't have the same cancer risk as traditional ranitidine, making it a safer option. The FDA approved a reformulated prescription-only version of ranitidine in late 2025. FDA Advises Consumers, Patients and Health Care Professionals After New FDA Studies Show Risk to Public Health. The U.S. Food and Drug Administration today announced it is requesting manufacturers. Ranitidine, sold under the brand name Zantac among others, is a medication used to decrease stomach acid production. [9] It is used in the treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. [9] Easy-to-read patient tips for Zantac covering how it works, benefits, risks, and best practices.